Altering the course of schizophrenia: progress and perspectives.
Identifieur interne : 002387 ( Main/Exploration ); précédent : 002386; suivant : 002388Altering the course of schizophrenia: progress and perspectives.
Auteurs : Mark J. Millan [France] ; Annie Andrieux [France] ; George Bartzokis [États-Unis] ; Kristin Cadenhead [États-Unis] ; Paola Dazzan [Royaume-Uni] ; Paolo Fusar-Poli [Royaume-Uni] ; Jürgen Gallinat [Allemagne] ; Jay Giedd [États-Unis] ; Dennis R. Grayson [États-Unis] ; Markus Heinrichs [Allemagne] ; René Kahn [Pays-Bas] ; Marie-Odile Krebs [France] ; Marion Leboyer [France] ; David Lewis [États-Unis] ; Oscar Marin [Royaume-Uni] ; Philippe Marin [France] ; Andreas Meyer-Lindenberg [Allemagne] ; Patrick Mcgorry [Australie] ; Philip Mcguire ; Michael J. Owen [Royaume-Uni] ; Paul Patterson [Royaume-Uni] ; Akira Sawa [États-Unis] ; Michael Spedding [France] ; Peter Uhlhaas [Royaume-Uni] ; Flora Vaccarino [États-Unis] ; Claes Wahlestedt [États-Unis] ; Daniel Weinberger [États-Unis]Source :
- Nature reviews. Drug discovery [ 1474-1784 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Schizophrénie.
- traitement médicamenteux : Schizophrénie.
- usage thérapeutique : Neuroleptiques.
- Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antipsychotic Agents.
- diagnosis : Schizophrenia.
- drug therapy : Schizophrenia.
- Humans.
Abstract
Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its genetic and environmental causes has considerably improved, and their relationship to aberrant patterns of neurodevelopment has become clearer. This raises the possibility that 'disease-modifying' strategies could alter the course to - and of - this debilitating disorder, rather than simply alleviating symptoms. A promising window for course-altering intervention is around the time of the first episode of psychosis, especially in young people at risk of transition to schizophrenia. Indeed, studies performed in both individuals at risk of developing schizophrenia and rodent models for schizophrenia suggest that pre-diagnostic pharmacotherapy and psychosocial or cognitive-behavioural interventions can delay or moderate the emergence of psychosis. Of particular interest are 'hybrid' strategies that both relieve presenting symptoms and reduce the risk of transition to schizophrenia or another psychiatric disorder. This Review aims to provide a broad-based consideration of the challenges and opportunities inherent in efforts to alter the course of schizophrenia.
DOI: 10.1038/nrd.2016.28
PubMed: 26939910
Affiliations:
- Allemagne, Australie, France, Pays-Bas, Royaume-Uni, États-Unis
- Auvergne-Rhône-Alpes, Bade-Wurtemberg, Berlin, District de Fribourg-en-Brisgau, District de Karlsruhe, Floride, Illinois, Rhône-Alpes, Écosse, Île-de-France
- Berlin, Chicago, Croissy-sur-Seine, Fribourg-en-Brisgau, Glasgow, Grenoble, Mannheim, Paris
- Université de Glasgow, Université de l'Illinois à Chicago
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Meyer-Lindenberg</name><affiliation wicri:level="3"><nlm:affiliation>Central Institute for Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Central Institute for Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Mcgorry, Patrick" sort="Mcgorry, Patrick" uniqKey="Mcgorry P" first="Patrick" last="Mcgorry">Patrick Mcgorry</name><affiliation wicri:level="1"><nlm:affiliation>Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Victoria 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, the National Centre of Excellence in Youth 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Glasgow, Glasgow G12 8QB</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Sawa, Akira" sort="Sawa, Akira" uniqKey="Sawa A" first="Akira" last="Sawa">Akira Sawa</name><affiliation wicri:level="1"><nlm:affiliation>Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland MD21205, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland MD21205</wicri:regionArea><wicri:noRegion>Maryland MD21205</wicri:noRegion></affiliation></author><author><name sortKey="Spedding, Michael" sort="Spedding, Michael" uniqKey="Spedding M" first="Michael" last="Spedding">Michael Spedding</name><affiliation wicri:level="1"><nlm:affiliation>Spedding Research Solutions SARL, 78110 le Vesinet, 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Millan</name><affiliation wicri:level="3"><nlm:affiliation>Pole for Innovation in Neuropsychiatry, Institut de Recherche (IDR) Servier, 78290 Croissy-sur-Seine, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pole for Innovation in Neuropsychiatry, Institut de Recherche (IDR) Servier, 78290 Croissy-sur-Seine</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Croissy-sur-Seine</settlement></placeName></affiliation></author><author><name sortKey="Andrieux, Annie" sort="Andrieux, Annie" uniqKey="Andrieux A" first="Annie" last="Andrieux">Annie Andrieux</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U836, Physiopathologie du cytosquelette, Grenoble Institut des Neurosciences, 38700 Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U836, Physiopathologie du cytosquelette, Grenoble Institut des Neurosciences, 38700 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Bartzokis, George" sort="Bartzokis, George" uniqKey="Bartzokis G" first="George" last="Bartzokis">George Bartzokis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, The David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, The David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095</wicri:regionArea><wicri:noRegion>California 90095</wicri:noRegion></affiliation></author><author><name sortKey="Cadenhead, Kristin" sort="Cadenhead, Kristin" uniqKey="Cadenhead K" first="Kristin" last="Cadenhead">Kristin Cadenhead</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093</wicri:regionArea><wicri:noRegion>California 92093</wicri:noRegion></affiliation></author><author><name sortKey="Dazzan, Paola" sort="Dazzan, Paola" uniqKey="Dazzan P" first="Paola" last="Dazzan">Paola Dazzan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF</wicri:regionArea><wicri:noRegion>London SE5 8AF</wicri:noRegion></affiliation></author><author><name sortKey="Fusar Poli, Paolo" sort="Fusar Poli, Paolo" uniqKey="Fusar Poli P" first="Paolo" last="Fusar-Poli">Paolo Fusar-Poli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF</wicri:regionArea><wicri:noRegion>London SE5 8AF</wicri:noRegion></affiliation></author><author><name sortKey="Gallinat, Jurgen" sort="Gallinat, Jurgen" uniqKey="Gallinat J" first="Jürgen" last="Gallinat">Jürgen Gallinat</name><affiliation wicri:level="3"><nlm:affiliation>Psychiatrische Universitätsklinik der Charité im Saint Hedwig-Krankenhaus, 10115 Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Psychiatrische Universitätsklinik der Charité im Saint Hedwig-Krankenhaus, 10115 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Giedd, Jay" sort="Giedd, Jay" uniqKey="Giedd J" first="Jay" last="Giedd">Jay Giedd</name><affiliation wicri:level="1"><nlm:affiliation>Child Psychiatry Branch, Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Child Psychiatry Branch, Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093</wicri:regionArea><wicri:noRegion>California 92093</wicri:noRegion></affiliation></author><author><name sortKey="Grayson, Dennis R" sort="Grayson, Dennis R" uniqKey="Grayson D" first="Dennis R" last="Grayson">Dennis R. Grayson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612</wicri:regionArea><orgName type="university">Université de l'Illinois à Chicago</orgName><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Heinrichs, Markus" sort="Heinrichs, Markus" uniqKey="Heinrichs M" first="Markus" last="Heinrichs">Markus Heinrichs</name><affiliation wicri:level="3"><nlm:affiliation>Freiburg Brain Imaging Center, University of Freiburg, 79106 Freiburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Freiburg Brain Imaging Center, University of Freiburg, 79106 Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Kahn, Rene" sort="Kahn, Rene" uniqKey="Kahn R" first="René" last="Kahn">René Kahn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CX Utrecht</wicri:regionArea><wicri:noRegion>3584 CX Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Krebs, Marie Odile" sort="Krebs, Marie Odile" uniqKey="Krebs M" first="Marie-Odile" last="Krebs">Marie-Odile Krebs</name><affiliation wicri:level="1"><nlm:affiliation>Service de Psychiatrie, Centre Hospitalier Sainte-Anne, 75014 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Psychiatrie, Centre Hospitalier Sainte-Anne, 75014 Paris</wicri:regionArea><wicri:noRegion>75014 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U955, Psychopathologie et génétique des maladies psychiatriques, 94000 Créteil, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U955, Psychopathologie et génétique des maladies psychiatriques, 94000 Créteil, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lewis, David" sort="Lewis, David" uniqKey="Lewis D" first="David" last="Lewis">David Lewis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213</wicri:regionArea><wicri:noRegion>Pennsylvania 15213</wicri:noRegion></affiliation></author><author><name sortKey="Marin, Oscar" sort="Marin, Oscar" uniqKey="Marin O" first="Oscar" last="Marin">Oscar Marin</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council (MRC) Centre for Developmental Neurobiology, King's College London, London SE1 1UL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council (MRC) Centre for Developmental Neurobiology, King's College London, London SE1 1UL</wicri:regionArea><wicri:noRegion>London SE1 1UL</wicri:noRegion></affiliation></author><author><name sortKey="Marin, Philippe" sort="Marin, Philippe" uniqKey="Marin P" first="Philippe" last="Marin">Philippe Marin</name><affiliation wicri:level="1"><nlm:affiliation>Le Centre National de la Recherche Scientifique (CNRS), UMR-5203, Institut de Génomique Fonctionnelle, F-34000 Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Le Centre National de la Recherche Scientifique (CNRS), UMR-5203, Institut de Génomique Fonctionnelle, F-34000 Montpellier</wicri:regionArea><wicri:noRegion>34000 Montpellier</wicri:noRegion><wicri:noRegion>34000 Montpellier</wicri:noRegion></affiliation></author><author><name sortKey="Meyer Lindenberg, Andreas" sort="Meyer Lindenberg, Andreas" uniqKey="Meyer Lindenberg A" first="Andreas" last="Meyer-Lindenberg">Andreas Meyer-Lindenberg</name><affiliation wicri:level="3"><nlm:affiliation>Central Institute for Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Central Institute for Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Mcgorry, Patrick" sort="Mcgorry, Patrick" uniqKey="Mcgorry P" first="Patrick" last="Mcgorry">Patrick Mcgorry</name><affiliation wicri:level="1"><nlm:affiliation>Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Victoria 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Victoria 3052</wicri:regionArea><wicri:noRegion>Victoria 3052</wicri:noRegion></affiliation></author><author><name sortKey="Mcguire, Philip" sort="Mcguire, Philip" uniqKey="Mcguire P" first="Philip" last="Mcguire">Philip Mcguire</name><affiliation><nlm:affiliation>Department of Psychosis Studies, Institute of Psychiatry, King's College London, London SE5 8AF UK.</nlm:affiliation><wicri:noCountry code="subField">London SE5 8AF UK</wicri:noCountry></affiliation></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J" last="Owen">Michael J. Owen</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff CF24 4HQ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff CF24 4HQ</wicri:regionArea><wicri:noRegion>Cardiff CF24 4HQ</wicri:noRegion></affiliation></author><author><name sortKey="Patterson, Paul" sort="Patterson, Paul" uniqKey="Patterson P" first="Paul" last="Patterson">Paul Patterson</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QB, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QB</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Sawa, Akira" sort="Sawa, Akira" uniqKey="Sawa A" first="Akira" last="Sawa">Akira Sawa</name><affiliation wicri:level="1"><nlm:affiliation>Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland MD21205, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland MD21205</wicri:regionArea><wicri:noRegion>Maryland MD21205</wicri:noRegion></affiliation></author><author><name sortKey="Spedding, Michael" sort="Spedding, Michael" uniqKey="Spedding M" first="Michael" last="Spedding">Michael Spedding</name><affiliation wicri:level="1"><nlm:affiliation>Spedding Research Solutions SARL, 78110 le Vesinet, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Spedding Research Solutions SARL, 78110 le Vesinet</wicri:regionArea><wicri:noRegion>78110 le Vesinet</wicri:noRegion><wicri:noRegion>78110 le Vesinet</wicri:noRegion></affiliation></author><author><name sortKey="Uhlhaas, Peter" sort="Uhlhaas, Peter" uniqKey="Uhlhaas P" first="Peter" last="Uhlhaas">Peter Uhlhaas</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QB, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QB</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Vaccarino, Flora" sort="Vaccarino, Flora" uniqKey="Vaccarino F" first="Flora" last="Vaccarino">Flora Vaccarino</name><affiliation wicri:level="1"><nlm:affiliation>Child Study Center, Yale School of Medicine, New Haven, Connecticut 06519, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Child Study Center, Yale School of Medicine, New Haven, Connecticut 06519</wicri:regionArea><wicri:noRegion>Connecticut 06519</wicri:noRegion></affiliation></author><author><name sortKey="Wahlestedt, Claes" sort="Wahlestedt, Claes" uniqKey="Wahlestedt C" first="Claes" last="Wahlestedt">Claes Wahlestedt</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioural Sciences, University of Miami Miller School of Medicine, Miami 33136, Florida, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioural Sciences, University of Miami Miller School of Medicine, Miami 33136, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Weinberger, Daniel" sort="Weinberger, Daniel" uniqKey="Weinberger D" first="Daniel" last="Weinberger">Daniel Weinberger</name><affiliation wicri:level="1"><nlm:affiliation>Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, Maryland MD21205, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, Maryland MD21205</wicri:regionArea><wicri:noRegion>Maryland MD21205</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature reviews. Drug discovery</title><idno type="eISSN">1474-1784</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antipsychotic Agents (therapeutic use)</term><term>Humans</term><term>Schizophrenia (diagnosis)</term><term>Schizophrenia (drug therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Neuroleptiques (usage thérapeutique)</term><term>Schizophrénie (diagnostic)</term><term>Schizophrénie (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antipsychotic Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Schizophrenia</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Schizophrénie</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Schizophrenia</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Schizophrénie</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Neuroleptiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its genetic and environmental causes has considerably improved, and their relationship to aberrant patterns of neurodevelopment has become clearer. This raises the possibility that 'disease-modifying' strategies could alter the course to - and of - this debilitating disorder, rather than simply alleviating symptoms. A promising window for course-altering intervention is around the time of the first episode of psychosis, especially in young people at risk of transition to schizophrenia. Indeed, studies performed in both individuals at risk of developing schizophrenia and rodent models for schizophrenia suggest that pre-diagnostic pharmacotherapy and psychosocial or cognitive-behavioural interventions can delay or moderate the emergence of psychosis. Of particular interest are 'hybrid' strategies that both relieve presenting symptoms and reduce the risk of transition to schizophrenia or another psychiatric disorder. This Review aims to provide a broad-based consideration of the challenges and opportunities inherent in efforts to alter the course of schizophrenia.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Berlin</li><li>District de Fribourg-en-Brisgau</li><li>District de Karlsruhe</li><li>Floride</li><li>Illinois</li><li>Rhône-Alpes</li><li>Écosse</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Chicago</li><li>Croissy-sur-Seine</li><li>Fribourg-en-Brisgau</li><li>Glasgow</li><li>Grenoble</li><li>Mannheim</li><li>Paris</li></settlement><orgName><li>Université de Glasgow</li><li>Université de l'Illinois à Chicago</li></orgName></list><tree><noCountry><name sortKey="Mcguire, Philip" sort="Mcguire, Philip" uniqKey="Mcguire P" first="Philip" last="Mcguire">Philip Mcguire</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Millan, Mark J" sort="Millan, Mark J" uniqKey="Millan M" first="Mark J" last="Millan">Mark J. Millan</name></region><name sortKey="Andrieux, Annie" sort="Andrieux, Annie" uniqKey="Andrieux A" first="Annie" last="Andrieux">Annie Andrieux</name><name sortKey="Krebs, Marie Odile" sort="Krebs, Marie Odile" uniqKey="Krebs M" first="Marie-Odile" last="Krebs">Marie-Odile Krebs</name><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><name sortKey="Marin, Philippe" sort="Marin, Philippe" uniqKey="Marin P" first="Philippe" last="Marin">Philippe Marin</name><name sortKey="Spedding, Michael" sort="Spedding, Michael" uniqKey="Spedding M" first="Michael" last="Spedding">Michael Spedding</name></country><country name="États-Unis"><noRegion><name sortKey="Bartzokis, George" sort="Bartzokis, George" uniqKey="Bartzokis G" first="George" last="Bartzokis">George Bartzokis</name></noRegion><name sortKey="Cadenhead, Kristin" sort="Cadenhead, Kristin" uniqKey="Cadenhead K" first="Kristin" last="Cadenhead">Kristin Cadenhead</name><name sortKey="Giedd, Jay" sort="Giedd, Jay" uniqKey="Giedd J" first="Jay" last="Giedd">Jay Giedd</name><name sortKey="Grayson, Dennis R" sort="Grayson, Dennis R" uniqKey="Grayson D" first="Dennis R" last="Grayson">Dennis R. Grayson</name><name sortKey="Lewis, David" sort="Lewis, David" uniqKey="Lewis D" first="David" last="Lewis">David Lewis</name><name sortKey="Sawa, Akira" sort="Sawa, Akira" uniqKey="Sawa A" first="Akira" last="Sawa">Akira Sawa</name><name sortKey="Vaccarino, Flora" sort="Vaccarino, Flora" uniqKey="Vaccarino F" first="Flora" last="Vaccarino">Flora Vaccarino</name><name sortKey="Wahlestedt, Claes" sort="Wahlestedt, Claes" uniqKey="Wahlestedt C" first="Claes" last="Wahlestedt">Claes Wahlestedt</name><name sortKey="Weinberger, Daniel" sort="Weinberger, Daniel" uniqKey="Weinberger D" first="Daniel" last="Weinberger">Daniel Weinberger</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Dazzan, Paola" sort="Dazzan, Paola" uniqKey="Dazzan P" first="Paola" last="Dazzan">Paola Dazzan</name></noRegion><name sortKey="Fusar Poli, Paolo" sort="Fusar Poli, Paolo" uniqKey="Fusar Poli P" first="Paolo" last="Fusar-Poli">Paolo Fusar-Poli</name><name sortKey="Marin, Oscar" sort="Marin, Oscar" uniqKey="Marin O" first="Oscar" last="Marin">Oscar Marin</name><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J" last="Owen">Michael J. Owen</name><name sortKey="Patterson, Paul" sort="Patterson, Paul" uniqKey="Patterson P" first="Paul" last="Patterson">Paul Patterson</name><name sortKey="Uhlhaas, Peter" sort="Uhlhaas, Peter" uniqKey="Uhlhaas P" first="Peter" last="Uhlhaas">Peter Uhlhaas</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Gallinat, Jurgen" sort="Gallinat, Jurgen" uniqKey="Gallinat J" first="Jürgen" last="Gallinat">Jürgen Gallinat</name></region><name sortKey="Heinrichs, Markus" sort="Heinrichs, Markus" uniqKey="Heinrichs M" first="Markus" last="Heinrichs">Markus Heinrichs</name><name sortKey="Meyer Lindenberg, Andreas" sort="Meyer Lindenberg, Andreas" uniqKey="Meyer Lindenberg A" first="Andreas" last="Meyer-Lindenberg">Andreas Meyer-Lindenberg</name></country><country name="Pays-Bas"><noRegion><name sortKey="Kahn, Rene" sort="Kahn, Rene" uniqKey="Kahn R" first="René" last="Kahn">René Kahn</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Mcgorry, Patrick" sort="Mcgorry, Patrick" uniqKey="Mcgorry P" first="Patrick" last="Mcgorry">Patrick Mcgorry</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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